Giampaolo Pazzini starts against the club he left in January, as Sampdoria welcome Inter with Andrea Ranocchia's amazing recovery.
This is set to be an emotional encounter for Pazzini, who was a hero to the Marassi fans before his sale towards the end of the transfer window.
He steps out with the blue and black shirt in Genoa for the first time and leads a 4-3-1-2 system with Wesley Sneijder supporting him and Samuel Eto'o.
It is also a special game for ex-Genoa defender Ranocchia, who was thought to be out of action for several weeks after suffering a knee injury during the 1-0 defeat to Bayern Munich.
However, he has made an incredible recovery to start in the back four, where Yuto Nagatomo takes the right-back role in place of the suspended Douglas Maicon.
Diego Milito, Ivan Cordoba and Walter Samuel are unavailable.
Sampdoria have to do without Franco Semioli, Nicola Pozzi and Fernando Tissone, but leave both Federico Macheda and ex-Inter striker Jonathan Biabiany on the bench.
Instead, Stefano Guberti is pushed up as support for lone centre-forward Massimo Maccarone with Reto Ziegler in a more advanced role, switching to a three-man defence.
Sampdoria: 85 Curci; 26 Volta, 28 Gastaldello, 6 Lucchini; 7 Mannini, 4 Dessena, 16 Poli, 17 Palombo, 3 Ziegler; 8 Guberti, 32 Maccarone
Sampdoria bench: 1 Da Costa, 11 Koman, 18 Laczko, 25 Martinez, 27 Biabiany, 41 Macheda, 78 Zauri
Inter: 1 Julio Cesar; 55 Nagatomo, 6 Lucio, 15 Ranocchia, 26 Chivu; 14 Kharja, 4 Zanetti, 5 Stankovic; 10 Sneijder; 7 Pazzini, 9 Eto'o
Inter bench: 12 Castellazzi, 8 Thiago Motta, 17 Mariga, 20 Obi, 23 Materazzi, 27 Pandev, 29 Coutinho