Momo Sissoko is out for the rest of the season after knee surgery, while Juventus also lose Fabio Grosso and Hasan Salihamidzic.
Sissoko required keyhole surgery to clear up cartilage in his left knee and the operation was performed in Bordeaux this morning.
Juve confirm the former Liverpool midfielder should be out of action for around three months, so the season is effectively over.
As he is expected to leave in the summer for a new club, Sissoko may well have played his last game for the Bianconeri.
Teammate Grosso is out for 10 days after tests confirmed a small right thigh strain.
Salihamidzic dropped out of today's training session with a problem at the back of his left thigh and will undergo further tests over the next 48 hours.