There's the very real risk Kevin-Prince Boateng could miss Milan's trip to Tottenham after he left the Olimpico on crutches.
The Rossoneri will attempt to overturn their 1-0 first leg defeat in the Champions League on Wednesday and Boateng had been a favourite to start.
However, he limped off at half-time during last night's 1-0 victory away to Juventus and left the Stadio Olimpico on crutches.
Boateng accidentally clashed with Felipe Melo, receiving a very hard kick to the ankle, which seemed to twist in an unnatural fashion.
He carried on playing for a few more minutes, but was replaced at the break and seems to be in poor shape.
There's a race against time to get the Ghana international fit for Wednesday's match at White Hart Lane.
Antonio Cassano, Mark Van Bommel and Urby Emanuelson are cup-tied, while Alexandre Pato and Massimo Oddo missed the Juventus game with flu symptoms.
It's likely that Clarence Seedorf will be given a starting spot in midfield instead.