Jeremy Menez, Marco Cassetti and Adriano are out of the trip to Donetsk, as Vincenzo Montella prepares for his Champions League debut with Roma.
The Coach is still unbeaten since taking over from Claudio Ranieri and hopes to overturn a 3-2 first leg defeat in Europe.
He will have to do without the injured Adriano, while Menez and Cassetti are suspended for the clash with Shakhtar.
It's believed Montella will opt for a trident attack with Francesco Totti, Mirko Vucinic and Marco Borriello.
David Pizarro is again set to push through the pain in order to play in midfield with Daniele De Rossi.
Roma squad: Lobont, Castellini, Juan, Mexes, Pizarro, Vucinic, Totti, Taddei, Loria, De Rossi, Riise, Perrotta, Borriello, Greco, G Burdisso, Julio Sergio, N Burdisso, Fabio Simplicio, Doni, Brighi, Pettinari, Caprari, Sabelli, Rosi
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more