Roma have rested Mirko Vucinic for the clash with Adrian Mutu's Fiorentina, so Francesco Totti partners Marco Borriello and Jeremy Menez.
The Giallorossi are fresh from their derby triumph and want to keep that momentum going with a very attacking line-up at the Olimpico.
Totti is back from suspension and with him returns the two-striker system with Borriello plus trequartista Menez.
Following his fine substitute performances, Leandro Greco is given a place in the starting XI.
Fiorentina's Juan Manuel Vargas has recovered in time to start this match along with Alberto Gilardino, Mario Alberto Santana, Mutu and Alberto Gilardino.
Former Roma youth products Gaetano D'Agostino and Alessio Cerci are on the bench.
Roma: Julio Sergio; Cicinho, Mexes, N Burdisso, Riise; Greco, De Rossi, Simplicio; Menez, Totti; Borriello
Roma bench: Lobont, Castellini, Vucinic, Baptista, Perrotta, Brighi, Rosi
Fiorentina: Boruc; De Silvestri, Gamberini, Natali, Pasqual; Donadel, Santana; Marchionni, Mutu, Vargas; Gilardino
Fiorentina bench: Avramov, Comotto, Kroldrup, D'Agostino, Ljajic, Bolatti, Cerci