Javier Zanetti returns in an all-attack line-up as Inter welcome Lecce in their bid to go within two points of leaders Milan.
The Nerazzurri have a huge opportunity to close in on the top spot after Milan's defeat to Palermo last night.
Ivan Cordoba is suspended with Diego Milito, Andrea Ranocchia and Walter Samuel injured, so there is a reshuffle at the back.
Zanetti returns after missing the Bayern Munich triumph with a fever and takes the left-back slot, moving Cristian Chivu into the centre.
As ever, Giampaolo Pazzini starts the Serie A games with Samuel Eto'o and Wesley Sneijder, but Goran Pandev is also included in a very attack-minded side.
Lecce are still in the relegation zone and have to do without David Di Michele, Edward Ofere, Javier Chevanton, Alberto Giuliatto and the suspended Gianni Munari.
Daniele Corvia is therefore the only centre-forward in a 4-5-1 system.
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 26 Chivu, 4 Zanetti; 19 Cambiasso, 8 Thiago Motta; 10 Sneijder; 27 Pandev, 7 Pazzini, 9 Eto'o.
Inter bench: 12 Castellazzi, 5 Stankovic, 14 Kharja, 17 Mariga, 23 Materazzi, 27 Pandev, 29 Coutinho
Lecce: 22 Rosati; 40 Tomovic, 13 Ferrario, 14 Fabiano, 28 Brivio; 10 Olivera, 20 Vives, 18 Giacomazzi 91 Bertolacci, 11 Mesbah; 9 Corvia.
Lecce bench: 81 Benassi, 2 Donati, 4 Gustavo, 19 Piatti, 21 Grossmuller, 27 Jeda, 32 Coppola