Napoli can go into second place with a victory against reshuffled Lazio in the lunch-time kick-off.
Following last night's 3-0 Milan derby result, the Vesuviani can overtake Inter in the Serie A table, but they haven't beaten Lazio here since December 1996.
The Stadio San Paolo is packed for the 11.30am UK time kick-off and the only absentees for Coach Walter Mazzarri are Juan Zuniga and Gianluca Grava.
The ‘Three Tenors' of Marek Hamsik, Ezequiel Lavezzi and Edinson Cavani take centre stage with Hassan Yebda chosen ahead of Walter Gargano.
Edy Reja spent five years at Napoli and took this side from Serie C1 to the top flight, so makes his first return to the stadium as an opponent.
He has plenty of problems to contend with in this battle for Champions League spots, as Francelino Matuzalem, Stefan Radu and Cristian Ledesma are all suspended.
Add injuries to Tommaso Rocchi, Mourad Meghni and Mobido Diakitè and there are few alternatives for the Coach.
He once again chooses Mauro Zarate in a pure centre-forward role with support from Alejandro Gonzalez, Stefano Mauri and Giuseppe Sculli, but has surprisingly left Hernanes on the bench.
Cristian Brocchi takes the ‘protective' position in front of the defence with Mark Bresciano.
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Pazienza, Yebda, Dossena; Hamsik; Cavani, Lavezzi
Napoli bench: Iezzo, Santacroce, Ruiz, Gargano, Sosa, Mascara, C Lucarelli
Lazio: Muslera; Lichtsteiner, Biava, Dias, Garrido; Brocchi, Bresciano; Gonzalez, Mauri, Sculli; Zarate
Lazio bench: Berni, Stendardo, Scaloni, Hernanes, Foggia, Floccari, Kozak