Ezequiel Lavezzi has been pushed into Edinson Cavani's centre-forward role as Napoli continue their Scudetto challenge in Bologna.
The Vesuviani need a victory to keep up with leaders Milan and retake second from Inter, who won on Saturday.
Capocannoniere Cavani is suspended, so Lavezzi is moved into his more advanced position, supported by Marek Hamsik and Giuseppe Mascara.
Gianluca Grava and Bologna's Gyorgy Garics are the only long-term injury absentees.
The Rossoblu have already secured safety and want to get back on track after last week's defeat to Brescia.
Veteran hitman Marco Di Vaio leads the way, as always, with Albin Ekdal and youngster Daniele Paponi.
This is a surprise choice from Coach Alberto Malesani, who leaves Gaston Ramirez and Riccardo Meggiorini on the bench.
Bologna also switch to a three-man defence to counter Napoli's system.
Bologna: Viviano; Moras, Portanova, Cherubin; Buscè, Perez, Mudingayi, Morleo; Ekdal; Paponi, Di Vaio
Bologna bench: Lupatelli, Britos, Rubin, Mutarelli, Della Rocca, Ramirez, Meggiorini
Napoli: De Sanctis; Campagnaro, Cannavaro, Ruiz; Maggio, Pazienza, Yebda, Dossena; Mascara, Hamsik; Lavezzi
Napoli bench: Iezzo, Santacroce, Aronica, Gargano, Zuniga, Sosa, Lucarelli