Zlatan Ibrahimovic returns to partner Alexandre Pato as Milan travel to Alberto Gilardino's Fiorentina.
The Rossoneri need a result to maintain the Serie A leadership after Napoli and Inter won this weekend.
Antonio Cassano sits out a ban, joining the injured Alessandro Nesta, Andrea Pirlo, Massimo Ambrosini, Daniele Bonera, Marek Jankulovski and Pippo Inzaghi.
However, Ibrahimovic returns after his two-match ban to partner on-form Pato with support from Kevin-Prince Boateng, pushing Robinho on to the bench.
Gennaro Gattuso is also rested in favour of Mathieu Flamini in midfield, while Mario Yepes steps in for Nesta.
Adrian Mutu sits out a ban for Fiorentina, while Stevan Jovetic is still sidelined, so Adem Ljajic takes the supporting role behind ex-Milan striker Gilardino.
Also providing creativity are Mario Alberto Santana, Juan Manuel Vargas and Riccardo Montolivo.
Fiorentina: Boruc; Comotto, Gamberini, Natali, Pasqual; Donadel, Montolivo; Vargas, Santana, Ljajic; Gilardino
Milan: Abbiati; Abate, Yepes, Thiago Silva, Zambrotta; Flamini, Van Bommel, Seedorf; Boateng; Pato, Ibrahimovic