Roma have dropped Mirko Vucinic so Jeremy Menez supports Francesco Totti against Javier Pastore's Palermo.
The 17.00 UK time kick-off is at the Stadio Olimpico, where many fans have brought in American flags to celebrate the takeover from Thomas Di Benedetto.
The Giallorossi are still in contention for a Champions League place and Vincenzo Montella has opted to make changes.
He dropped Vucinic and Marco Borriello to the bench in favour of Menez, Rodrigo Taddei and Totti.
Simone Loria steps in for the suspended Juan, as Philippe Mexes and Julio Sergio are sidelined.
Palermo welcomed back Coach Delio Rossi last week, but threw away a 2-0 lead to draw with Cesena in stoppages.
Pastore has recovered from his injury to start with Mauricio Pinilla and Abel Hernandez, so Fabrizio Miccoli is left on the touchline.
Josip Ilicic is still dealing with his fitness problems, so Giulio Migliaccio returns to a midfield role.
Some of the changes are because Rossi is looking ahead to the Coppa Italia semi-final against Milan.
Roma: 32 Doni; 77 Cassetti, 29 N Burdisso, 15 Loria, 17 Riise; 7 Pizarro, 16 De Rossi; 87 Rosi, 94 Menez, 11 Taddei; 10 Totti
Roma bench: 1 Lobont, 3 Castellini, 33 Brighi, 23 Greco, 20 Perrotta, 9 Vucinic, 22 Borriello
Palermo: 46 Sirigu; 16 Cassani, 3 Goian, 5 Bovo, 42 Balzaretti; 8 Migliaccio, 21 Bacinovic, 23 Nocerino; 27 Pastore; 51 Pinilla, 9 Hernandez
Palermo bench: 99 Benussi, 36 Darmian, 6 Munoz, 94 Acquah, 11 Liverani, 77 Kurtic, 10 Miccoli