Gigi Buffon and Adrian Mutu return, but Alex Del Piero is benched as Juventus visit old rivals Fiorentina.
This is always a grudge match and Coach Sinisa Mihajlovic noted “a win over Juve is worth the Scudetto” to Viola fans.
Mutu returns from suspension, but Mario Alberto Santana, Cesare Natali and Stevan Jovetic are out.
Alessio Cerci steps in to replace Santana in the trio supporting Alberto Gilardino.
Juventus' slender hopes of a Champions League spot were boosted by Roma's defeat to Palermo on Saturday.
Buffon and Del Piero return to the fold after their injury woes, but the treatment table remains packed.
Unavailable are Giorgio Chiellini, Zdenek Grygera, Paolo De Ceglie, Leandro Rinaudo, Momo Sissoko, Fabio Quagliarella and Vincenzo Iaquinta.
Gigi Del Neri sticks with his 4-3-3 system, as Milos Krasic and Simone Pepe flank Alessandro Matri.
It means Del Piero and ex-Fiorentina hero Luca Toni are on the bench.
The Bianconeri are unbeaten in Florence since Gabriel Batistuta got the only goal in 1998.
Fiorentina: Boruc; De Silvestri, Gamberini, Kroldrup, Pasqual; Behrami, Montolivo; Vargas, Cerci, Mutu; Gilardino
Fiorentina bench: Frey, Donadel, Babacar, D'Agostino, Comotto, Ljajic, Camporese
Juventus: Buffon; Motta, Bonucci, Barzagli, Grosso; Aquilani, Felipe Melo, Marchisio; Krasic, Matri, Pepe
Juventus bench: Storari, Salihamidzic, Del Piero, Traoré, Toni, Martinez, Sorensen
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more