Claudio Marchisio has left Italy's training base after he was ruled out of Wednesday's friendly against Romania.
The Juventus ace, who was replaced in Saturday's 1-1 draw against Roma, is struggling with a muscle problem in his right leg.
Former Under-21 international Marchisio underwent medical tests in Florence earlier today which illustrated a slight problem.
Although the issue is not thought to be very serious, Italy boss Cesare Prandelli doesn't want to run any risks.
The tactician has sent Marchisio back to Turin where club medics will try to get him ready for Sunday lunchtime's game at Genoa.
The omission of Marchisio may increase the chances of Lazio's Cristian Ledesma making his international debut.