Diego Milito and Goran Pandev form a new partnership against Mirko Vucinic and Marco Borriello in tonight's Roma-Inter Coppa Italia semi-final.
This is the first leg of the semi at the Stadio Olimpico and the last real chance for either side to pick up more silverware this season.
Francesco Totti is still suspended after his red card in last year's Final against Inter for a horrific tackle on Mario Balotelli. Julio Sergio and Philippe Mexes are injured.
Borriello leads the line with support from Vucinic, Simone Perrotta and Rodrigo Taddei.
Inter are also missing a talisman, as Samuel Eto'o has been ruled out with a knee injury, joining ex-Roma defender Walter Samuel on the treatment table.
It gives Milito the opportunity to start alongside Pandev, who is the surprise pick ahead of Giampaolo Pazzini.
Leonardo needs a boost after consecutive defeats to Schalke and Parma, so brings back Douglas Maicon, who was frozen out for failing to put enough effort into training.
Wesley Sneijder also returns to the starting XI with Yuto Nagatomo again in defence.
Roma: 32 Doni; 77 Cassetti, 29 N Burdisso, 4 Juan, 17 Riise; 7 Pizarro, 16 De Rossi; 11 Taddei, 20 Perrotta, 9 Vucinic; 22 Borriello
Roma bench: 1 Lobont, 3 Castellini, 15 Loria, 30 Simplicio, 33 Brighi, 87 Rosi, 94 Menez
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 15 Ranocchia, 55 Nagatomo; 4 Zanetti, 19 Cambiasso, 5 Stankovic; 10 Sneijder; 27 Pandev, 22 Milito
Inter bench: 12 Castellazzi, 7 Pazzini, 14 Kharja, 17 Mariga, 20 Obi, 23 Materazzi, 26 Chivu