Giuseppe Sculli also looks to miss out on Saturday's game, but President Claudio Lotito believes Lazio “will be competitive” against Inter.
This is a head-to-head for third place and the last automatic qualifying spot for the Champions League group phase.
Stephan Radu has been ruled out for the rest of the season after fracturing bones in his back, while there are reports Sculli will also be sidelined with a less serious back problem.
“It will be a very difficult game, but Lazio will be competitive,” said President Lotito.
“We need every member of the squad to give their best, plus the whole club and the fans. We are going to face one of the best sides in Serie A.”
The Biancocelesti are fired up after their 4-1 demolition of Catania last week.
“I hope to see the same attitude from the team, which is to be humble, hungry and determined.
“We need a team spirit and a united group, as everyone has to work in the same direction.”