Milan have a new trio of Antonio Cassano, Kevin-Prince Boateng and Robinho to break even further away at the top against an attack-minded Brescia.
With Napoli's defeat today, a win at the Stadio Rigamonti would put the Rossoneri eight points clear with only four games to go. Kick-off is at 18.00 UK time.
Options in attack are limited for Max Allegri, as Zlatan Ibrahimovic is suspended with Alexandre Pato, Pippo Inzaghi, Alessandro Nesta and Marek Jankulovski injured.
It means the only strikers available are all in the starting XI, as Cassano, Boateng and Robinho form a new trident.
Andrea Pirlo and Massimo Ambrosini are back in the squad after four months on the touchline. Gennaro Gattuso pulled out during the warm-up to make way for Mathieu Flamini.
Brescia are increasingly desperate and this afternoon's results have made their situation even worse.
Sampdoria's win over Bari means they are five points adrift of the safety zone and locked in penultimate place even with a victory over Milan.
Davide Zoboli is suspended in defence, while Eder returns from his ban to partner Andrea Caracciolo.
There were reports it would be a 3-5-2 system, but instead Alessandro Diamanti acts as trequartista behind the strikers.
Absent through injury are Simone Dallamano and Nicolas Cordova.
Brescia: Arcari; Zambelli, Zebina, Bega; Berardi, Vass, Zanetti, Hetemaj; Diamanti; Eder, Carracciolo
Milan: Abbiati; Abate, Thiago Silva, Yepes, Zambrotta; Gattuso, Van Bommel, Seedorf; Boateng; Cassano, Robinho