Giampaolo Pazzini is benched again, but Inter switch to a 4-2-3-1 system in Wesley Sneijder's absence against Cesena.
The Nerazzurri step out at the Stadio Dino Manuzzi this afternoon, kick-off at 17.00 UK time.
Sneijder pulled out with an injury along with Dejan Stankovic, Walter Samuel and Ivan Cordoba.
Leonardo has opted to transform the tactics instead, using Goran Pandev, Thiago Motta and Samuel Eto'o to fan out behind lone centre-forward Diego Milito.
Once again, there is no room for Pazzini, who has been dropped repeatedly in recent weeks.
Luca Castellazzi steps in for suspended goalkeeper Julio Cesar, while Yuto Nagatomo faces his former teammates.
Cesena are battling against relegation and missing Ivan Fatic, Dias Felipe, Alessandro Rosina and the suspended Giuseppe Colucci.
Davide Santon was named in the starting XI, but suffered an injury during the warm-up and has been replaced by Luca Ceccarelli.
Erjon Bogdani is only fit for the bench, so Igor Budan starts in attack with support from Emanuele Giaccherini and ex-Inter man Luis Jimenez.
Cesena: 1 Antonioli; 46 Santon, 25 Von Bergen, 3 Pellegrino, 6 Lauro; 24 Sammarco, 8 Caserta, 18 Parolo; 23 Giaccherini, 10 Jimenez; 11 Budan
Cesena bench: 33 Calderoni, 15 Benalouane, 17 Malonga, 19 Gorobsov, 44 Piangerelli, 70 Bogdani
Inter: 12 Castellazzi; 13 Maicon, 6 Lucio, 15 Ranocchia, 55 Nagatomo; 4 Zanetti, 19 Cambiasso; 27 Pandev, 8 Thiago Motta, 9 Eto'o; 22 Milito
Inter bench: 21 Orlandoni, 7 Pazzini, 14 Kharja, 17 Mariga, 20 Obi, 23 Materazzi, 26 Chivu
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more