Massimo Ambrosini returns to the starting XI as Robinho and Antonio Cassano welcome Bologna on Milan's road to the Scudetto.
The Rossoneri cannot clinch the title this weekend because both Inter and Napoli won their games on Saturday.
They do still need four points from the remaining four rounds to mathematically be sure of the Serie A crown.
Mark Van Bommel has joined Zlatan Ibrahimovic on the list of banned players, while Alexandre Pato, Pippo Inzaghi, Gennaro Gattuso and Marek Jankulovski are injured.
Ambrosini returns for his first start in three months, while Clarence Seedorf completes the midfield with Mathieu Flamini.
The only forwards available are Kevin-Prince Boateng supporting Robinho and Cassano.
Bologna thought they had done enough to secure their safety, but after four straight defeats risk being sucked back into the relegation zone.
Alberto Malesani is under pressure and has to do without Diego Perez, Antonio Busce', Gyorgy Garics and Andrea Esposito.
Marco Di Vaio is the lone centre-forward with Albin Ekdal, Riccardo Meggiorini and Matteo Rubin providing support.
Milan: Abbiati, Abate, Nesta, Thiago Silva, Zambrotta, Flamini, Ambrosini, Seedorf, Boateng, Robinho, Cassano
Bologna: Viviano, Moras, Portanova, Britos, Cherubin, Mutarelli, Mudingayi, Meggiorini, Ekdal, Rubin, Di Vaio
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!