Mauro Zarate takes on Alessandro Del Piero in tonight's Serie A clash, as Lazio try to maintain fourth against a desperate Juventus.
Gigi Del Neri may claim the Bianconeri still have a chance of qualifying for the Champions League, but failure to win this evening would end even those slim hopes.
Giorgio Chiellini is ready for his first start in six weeks to send Leonardo Bonucci to the bench, though Claudio Marchisio, Marco Storari and Zdenek Grygera join the long-term injury list.
Alessandro Matri and Del Piero are the front two, so Luca Toni remains on the bench.
Lazio have to do without Mobido Diakitè, Stephan Radu, Guglielmo Stendardo, Pasquale Foggia, Giuseppe Sculli, Mourad Meghni and the suspended Stefano Mauri.
Zarate retains his spot in attack with Sergio Floccari, while Christian Brocchi returns from his injury problems.
The Biancocelesti are currently in fourth place, but have only a one-point advantage over both Roma and Udinese.
Lazio: 86 Muslera; 2 Lichtsteiner, 20 Biava, 3 Dias, 14 Garrido; 8 Hernanes, 24 Ledesma, 11 Matuzalem, 32 Brocchi; 22 Floccari, 10 Zarate
Lazio bench: 12 Berni, 5 Scaloni, 81 Del Nero, 23 Bresciano, 15 Gonzales, 9 Rocchi, 18 Kozak
Juventus: 1 Buffon; 2 Motta, 15 Barzagli, 3 Chiellini, 6 Grosso; 27 Krasic, 4 Felipe Melo, 14 Aquilani, 23 Pepe; 32 Matri, 10 Del Piero
Juventus bench: 13 Manninger, 43 Sorensen, 19 Bonucci, 17 Traore, 7 Salihamidzic, 36 Giandonato, 20 Toni