Wesley Sneijder, Dejan Stankovic, Lucio and Ivan Cordoba are out of Inter's trip to Napoli.
There were injury doubts over all the players and they have been left at home to train ahead of the Coppa Italia Final with Palermo.
Sneijder, Stankovic and Cordoba have missed recent games, but Lucio was a late addition with a slight ankle sprain.
It could mean Marco Materazzi getting a rare start at centre-back against Napoli on Sunday night.
Another option would be moving Cristian Chivu to the middle with Andrea Ranocchia so that Yuto Nagatomo can play on the wing.
Inter squad: 1 Julio Cesar, 12 Luca Castellazzi, 21 Paolo Orlandoni; 4 Javier Zanetti, 13 Maicon, 15 Andrea Ranocchia, 23 Marco Materazzi, 25 Walter Samuel, 26 Cristian Chivu, 37 Marco Davide Faraoni, 55 Yuto Nagatomo; 8 Thiago Motta, 14 Houssine Kharja, 17 MacDonald Mariga, 19 Esteban Cambiasso, 20 Joel Obi, 29 Philippe Coutinho; 7 Giampaolo Pazzini, 9 Samuel Eto'o, 22 Diego Milito, 27 Goran Pandev
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more