Roma trust in the trident attack of Mirko Vucinic, Francesco Totti and Marco Borriello against already-relegated Sampdoria.
The Giallorossi need only a point – or even a defeat if Juventus fail to beat Napoli – in order to secure Europa League football.
Daniele De Rossi is still suspended, but Simone Perrotta returns from his ban, while Matteo Brighi and Philippe Mexes are injured.
Coach Vincenzo Montella has gone for the trident attack with Totti, Vucinic and Borriello together in a 4-3-3 system.
Bogdan Lobont is given a rare start in goal, as Alexander Doni is sidelined, but Jeremy Menez is again benched.
Sampdoria are already doomed to Serie B, but field their full-strength side at the Stadio Olimpico.
Jonathan Biabiany and Nicola Pozzi lead the attack with captain Angelo Palombo in midfield.
Roma: 1 Lobont, 87 Rosi, 29 N. Burdisso, 15 Loria, 17 Riise, 11 Taddei, 7 Pizarro, 20 Perrotta, 10 Totti, 9 Vucinic, 22 Borriello
Sampdoria: 1 Da Costa, 78 Zauri, 26 Volta, 25 Martinez, 3 Ziegler, 7 Mannini, 12 Tissone , 17 Palombo, 18 Laczko, 9 Pozzi, 27 Biabiany
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!