Ronaldinho is benched again in Milan's trip to Sampdoria, while Under-21 international Guido Marilungo partners Giampaolo Pazzini.
The 17.00 UK time kick-off at Marassi sees the Serie A leaders in action to keep hold of top spot.
Despite complaining of fatigue, there is no rest for Zlatan Ibrahimovic, who again starts up front with Clarence Seedorf and Robinho.
It means Ronaldinho is benched for the sixth game on the trot, despite scoring as a substitute in the 2-0 win at Auxerre this week.
Andrea Pirlo, Massimo Oddo, Luca Antonini, Alexandre Pato and Pippo Inzaghi are injured, but Kevin Prince Boateng is chosen in midfield rather than Mathieu Flamini.
Sampdoria are naturally without Antonio Cassano, who has been frozen out of the squad, but captain Angelo Palombo is back to full fitness.
Under-21 international Marilungo got the nod ahead of Nicola Pozzi to partner Pazzini.
Sampdoria: Curci; Volta, Lucchini, Gastaldello, Ziegler; Mannini, Palombo, Tissone, Guberti; Pazzini, Marilungo
Milan: Abbiati; Abate, Nesta, Thiago Silva, Bonera; Gattuso, Ambrosini, Boateng; Seedorf; Ibrahimovic, Robinho
Tickets for the Champions League final between Juventus and Real Madrid are still on sale with reseller Viagogo - Click to find out more