Davide Santon is pushed to an advanced role as Inter readjust without Samuel Eto'o, while Sebastian Giovinco starts for Parma in the lunchtime kick-off.
This is the first test without Eto'o, who begins his three-match ban for head-butting Chievo's Bostjan Cesar in the chest during an off-the-ball incident.
He adds to the catalogue of absentees in Rafa Benitez's side, joining the injured Philippe Coutinho, Cristian Chivu, MacDonald Mariga, Julio Cesar, Diego Milito, Douglas Maicon, Joel Obi, Walter Samuel and David Suazo.
The Coach has been forced to make adjustments, as Goran Pandev is the only fit striker and takes over the centre-forward role.
Jonathan Biabiany and Wesley Sneijder are joined by full-back Santon in an unusual advanced position.
Parma also have problems to deal with, as Alberto Paloschi, Daniele Galloppa, Stefano Morrone and Fernando Marques are sidelined.
Former Inter and Milan striker Hernan Crespo is back at San Siro as a partner for Giovinco in a 4-4-2 formation.
It is an important comeback for Giovinco (pictured), who has been suffering from muscular problems for several weeks.
Kick-off is at 11.30 UK time and we will have a half-time report on the Football Italia website.
Inter: 12 Castellazzi; 2 Cordoba, 6 Lucio, 23 Materazzi, 4 Zanetti; 5 Stankovic, 19 Cambiasso; 88 Biabiany, 10 Sneijder, 39 Santon; 27 Pandev
Inter bench: 21 Orlandoni, 8 Thiago Motta, 31 Alibec, 34 Biraghi, 36 Benedetti, 40 Nwankwo, 57 Natalino
Parma: 83 Mirante; 5 Zaccardo, 29 Paletta, 6 Lucarelli, 3 Antonelli; 13 Angelo, 10 Dzemaili, 7 Candreva, 18 Gobbi; 21 Giovinco, 9 Crespo
Parma bench: 1 Pavarini, 22 Ze Eduardo, 24 Paci, 26 Pisano, 51 Della Fiore, 80 Valiani, 86 Bojinov