It's Francesco Totti and Jeremy Menez against Fabrizio Miccoli and Javier Pastore in an exciting showdown in Sicily.
Roma could go into third place with a victory at the Stadio Barbera, but a Palermo win would allow them to leapfrog the Giallorossi.
Mirko Vucinic, Adriano, Simone Perrotta, Leandro Greco, Rodrigo Taddei and Stefano Okaka are out of action with Nicolas Burdisso suspended.
Totti and David Pizarro therefore return to the starting XI alongside Menez and Marco Borriello, while former Palermo star Fabio Simplicio plays in midfield.
The home side have Fabio Liverani on the bench after his long injury lay-off, while Pastore, Miccoli and Josip Ilicic lead the attack.
There are no concerns about snow in Sicily, as it's 22 degrees Celsius.
Palermo: 46 Sirigu, 16 Cassani, 6 Munoz, 5 Bovo, 42 Balzaretti, 8 Migliaccio, 21 Bacinovic, 23 Nocerino, 27 Pastore, 72 Ilicic, 10 Miccoli
Palermo bench: 99 Benussi, 29 Garcia, 3 Goian, 4 Kasami, 11 Liverani, 32 Maccarone, 52 Pinilla
Roma: 27 Julio Sergio; 77 Cassetti, 5 Mexes, 4 Juan, 17 Riise; 30 Simplicio, 7 Pizarro, 16 De Rossi; 94 Menez; 10 Totti, 9 Borriello
Roma bench: 1 Lobont, 25 G. Burdisso, 2 Cicinho, 3 Castellini, 33 Brighi, 87 Rosi, 19 Baptista