Udinese's preparations for the Champions League preliminary round took a knock with their defeat to Nice, while Genoa lost against Padova.
The Friulani have been notching up a series of very impressive victories this summer, but hit problems on Saturday night in France.
There was bad luck, as Nice took the lead when a Hellebuyck shot took a decisive deflection off Mehdi Benatia.
More misfortune struck after Maurizio Domizzi limped off with a left thigh injury, then Antonio Di Natale hit the woodwork from point-blank range.
Fine saves managed to deny Diego Fabbrini and Di Natale, so Udinese were defeated 1-0.
Genoa fared even worse, as they lost to Serie B side Padova last night. Former Genoa man Dejan Lazarevic was decisive in the 1-0 result, curling a magnificent shot past Cristiano Lupatelli.