Juventus are relying on Fabio Quagliarella and Vincenzo Iaquinta to face Maxi Lopez's Catania, who are unbeaten on home turf.
The Stadio Massimino hosts the Sunday evening game with kick-off at 19.45 UK time.
Gigi Del Neri has a typically huge injury list missing Gigi Buffon, Leandro Rinaudo, Zdenek Grygera, Paolo De Ceglie, Jorge Martinez and Amauri.
Claudio Marchisio is also suspended, so Alberto Aquilani and Felipe Melo are the midfield partnership with Simone Pepe wide left.
Alessandro Del Piero is rested in favour of Quagliarella and Iaquinta, while teenager Frederik Sorensen replaces Marco Motta.
The conditions are radically different from at Lech Poznan midweek, where Juventus played in -15C temperatures, as it's closer to 20C in Sicily.
Catania must do without Giuseppe Bellusci, Nicolas Spolli and Blajez Augustyn, but have Maxi Lopez back from a ban.
The Argentine has been repeatedly linked with a January transfer to Juve, so will be eager to impress, and he is supported by Rafael Martinho and Taka Morimoto.
Catania: Andujar; Potenza, Silvestre, Terlizzi, Alvarez; Ledesma, Biagianti, Martinho, Gomez; Morimoto, Maxi Lopez
Catania bench: Campagnolo, Carboni, Capuano, Izco, Mascara, Ricchiuti, Antenucci
Juventus: Storari; Sorensen, Bonucci, Chiellini, Grosso; Krasic, Felipe Melo, Aquilani, Pepe; Quagliarella, Iaquinta
Juventus bench: Manninger, Motta, Legrottaglie, Sissoko, Salihamidzic, Lanzafame, Del Piero