Napoli begin their Serie A campaign on the artificial pitch at Cesena's Stadio Manuzzi with Edinson Cavani and Ezequiel Lavezzi.
The Partenopei kick off this evening at 19.45 UK time, but also have an eye on the Champions League clash with Manchester City.
This is why Marek Hamsik is rested along with Goran Pandev, so Mario Alberto Santana and Lavezzi support Cavani in attack.
Walter Gargano is suspended, so new buys Blerim Dzemaili and Gokhan Inler take the midfield reins, while Marco Donadel and Miguel Angel Britos are injured.
Cesena debut their new artificial pitch at the Stadio Manuzzi, so this is the first Serie A game to be played on a synthetic surface.
Martinho, Rodriguez and Francesco Antonioli are out of action, so goalkeeper Nicola Ravaglia gets his Serie A debut.
There were injury doubts over Adrian Mutu due to a muscular problem, but he has come out for the warm-up.
Cesena: Ravaglia; Comotto, Benalouane, Von Bergen, Lauro; Parolo, Guana, Colucci; Eder, Mutu, Candreva
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Inler, Dzemaili, Dossena; Santana, Lavezzi; Cavani
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!