Inter leave out Wesley Sneijder, but have Diego Forlan, Mauro Zarate and Diego Milito together against the all-new Palermo.
The Nerazzurri begin their campaign under Coach Gian Piero Gasperini, who is returning to the 3-4-3 system he favoured throughout his career.
The experiments of having Sneijder in midfield have been abandoned, as the Dutchman sits on the bench in favour of a trident attack with new buys Forlan, Zarate and old hand Milito.
Brazilian Jonathan is in for the injured Douglas Maicon. In fact, of the starting XI only Dejan Stankovic and Yuto Nagatomo are not from South America.
Emiliano Viviano, Ivan Cordoba, Thiago Motta, Cristian Chivu and Andrea Poli are all out of action.
Palermo have had a chaotic summer, as they went out of the Europa League and Coach Stefano Pioli was sacked on September 1, so youth team manager Devis Mangia was promoted.
It remains to be seen if he's a stop-gap solution, but the fact remains the Rosanero have nothing to lose this evening.
Greek goalkeeper Alexandros Tzorvas gets his Serie A debut, while Josip Ilicic supports Abel Hernandez and Fabrizio Miccoli in attack.
Palermo: 33 Tzorvas; 31 Pisano, 3 Silvestre, 8 Migliaccio, 42 Balzaretti; 90 E. Alvarez, 5 Barreto, 7 Della Rocca, 27 Ilicic; 11 Hernandez, 10 Miccoli
Palermo bench: 99 Benussi, 2 Mantovani, 4 Cetto, 14 Bertolo, 20 Acquah, 16 Zahavi, 51 Pinilla
Inter: 1 Julio Cesar; 6 Lucio, 25 Samuel, 4 Zanetti; 42 Jonathan, 5 Stankovic, 19 Cambiasso, 55 Nagatomo; 28 Zarate, 22 Milito, 9 Forlan
Inter bench: 21 Orlandoni, 23 Ranocchia, 20 Obi, 11 Alvarez, 10 Sneijder, 30 Castaignos, 7 Pazzini
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!