Tommaso Rocchi and Djibril Cissè lead out Lazio in their Europa League opener against Romanians Vaslui.
The Group D game kicks off at 18.00 UK time at the Stadio Olimpico and Edy Reja's men are hoping to follow on from their impressive 2-2 draw with Milan last Friday.
Federico Marchetti steps in after missing the Serie A tie due to suspension, but Miroslav Klose is rested in favour of veteran Rocchi. Stefano Mauri has picked up a thigh problem in training.
Rocchi is supported by the trident of Alvaro Gonzalez, Cissè and Giuseppe Sculli. There are changes at the back too, as Mobido Diakitè and Senad Lulic step in.
Romanian side Vaslui have some familiar faces in their squad, most notably former Hellas Verona and Bologna striker Martins Adailton.
They also adopt a 4-2-3-1 system to mirror Lazio's tactics.
Lazio: Marchetti; Zauri, Diakitè, Dias, Lulic; Ledesma, Matuzalem; Gonzalez, Sculli, Cissè; Rocchi
Lazio bench: Bizzarri, Biava, Konko, Hernanes, Brocchi, Ceccarelli, Kozak
Vaslui: Cerniauskas; Milanov, Farkas, Balaur, Milisavljevic; Pavlovic, Zmeu; Adailton, Wesley, Sanmartean; Temwanjera
Vaslui bench: Puia, Costin, Neagu, Gheorghiu, Bello, Willian Gerlem, Buhaescu
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!