Inter field an all-new trident and 3-4-3 system in tonight's trip to Serie A new boys Novara, as Gian Piero Gasperini drops Giampaolo Pazzini again.
The Nerazzurri are incredibly level with Novara on one point after two rounds, having lost at Palermo and drawn with Roma.
They have to do without the injured Dejan Stankovic, Douglas Maicon, Thiago Motta, Andrea Poli and Emiliano Viviano, though Cristian Chivu is back in the starting XI.
Gasperini was widely expected to give Pazzini his first start of the campaign, but instead opted for Luc Castaignos with Diego Forlan and Diego Milito.
Once again, Wesley Sneijder is used in a central midfield position, but this time it is a return to the 3-4-3 system after playing 3-5-2 against Roma.
Novara have had a relatively bright start to the season, which is their first foray into Serie A for 55 years.
They fought back from 2-0 down to grab a draw at Chievo, then fell to current surprise leaders Cagliari at the weekend.
Alex Pinardi is the only absentee, so Riccardo Meggiorini returns to partner Taka Morimoto.
Coach Attilio Tesser has Jeda and Pablo Granoche to draw on from the bench.
It is Novara's first home match of the campaign and it will be intriguing to see how Inter deal with the artificial pitch at the Stadio Silvio Piola.
Unlike Cesena, who had their synthetic turf installed over the summer, Novara have been playing on this surface for over a year and hope it can further aid home advantage.
The Week 4 opener kicks off at 19.45 UK time.
Novara: 1 Ujkani; 15 Dellafiore, 24 Paci, 4 Lisuzzo, 3 Gemiti; 17 Porcari, 23 Radovanovic,10 Rigoni; 21 Mazzarani; 11 Morimoto, 69 Meggiorini
Novara bench: 31 Fontana, 2 Giorgi, 5 Ludi, 14 Morganella, 18 Marianini, 20 Granoche, 27 Jeda
Inter: 1 Julio Cesar; 6 Lucio, 26 Chivu, 23 Ranocchia; 4 Zanetti, 19 Cambiasso, 10 Sneijder, 55 Nagatomo; 9 Forlan, 22 Milito, 30 Castaignos
Inter bench: 12 Castellazzi, 7 Pazzini, 20 Obi, 25 Samuel, 28 Zarate, 29 Coutinho, 42 Jonathan