Milan only make one change from the side that lost at Napoli, welcoming Udinese's Gabriel Torje and Antonio Di Natale.
Serie A Week 4 is a midweek round with the majority of games played tonight at 19.45 UK time.
Massimiliano Allegri has an injury crisis on his hands that has ruled out Zlatan Ibrahimovic, Robinho, Kevin-Prince Boateng, Gennaro Gattuso, Massimo Ambrosini, Daniele Bonera and Luca Antonini.
His options are therefore very limited, so the only change from the side that lost 3-1 to Napoli on Sunday is Gianluca Zambrotta stepping in for Bonera at left-back.
Clarence Seedorf and Alberto Aquilani can again rotate the trequartista role behind Antonio Cassano and Alexandre Pato.
Udinese are flying high at the top of the table with a 100 per cent record and not a single goal conceded in Serie A.
New signing Torje has been very impressive so far and is nicknamed ‘The Romanian Lionel Messi.'
He joins Di Natale, the veteran who has topped the Capocannoniere charts for two years running.
Francesco Guidolin is tweaking his side for this match by fielding a four-man defence.
Last season this fixture was a spectacular 4-4 draw.
Milan: Abbiati; Abate, Nesta, Thiago Silva, Zambrotta; Nocerino, Van Bommel, Seedorf; Aquilani; Cassano, Pato
Udinese: Handanovic; Benatia, Danilo, Domizzi, Basta; Isla, Badu, Asamoah, Armero; Torje, Di Natale