Wesley Sneijder and Dejan Stankovic are out of Inter's trip to Bologna on Saturday afternoon.
It will be Claudio Ranieri's first game in charge of the Nerazzurri, who are still without a win in all competition this season.
Sneijder limped off during the 3-1 defeat to Novara on Tuesday night with a thigh problem that has still not healed, so he is not even in the squad.
Stankovic also misses out along with Ivan Cordoba, Douglas Maicon, Thiago Motta, Andrea Poli and Emiliano Viviano.
Defender Andrea Ranocchia begins his three-match ban for a red card and insulting the official in Novara.
The game kicks off at the Stadio Dall'Ara at 17.00 UK time.
Inter squad: 1 Julio Cesar, 12 Luca Castellazzi, 21 Paolo Orlandoni; 6 Lucio, 25 Walter Samuel, 26 Cristian Chivu, 37 Davide Faraoni, 42 Jonathan, 55 Yuto Nagatomo; 4 Javier Zanetti, 11 Ricardo Alvarez, 19 Esteban Cambiasso, 20 Joel Obi, 29 Coutinho, 77 Sulley Muntari; 7 Giampaolo Pazzini, 9 Diego Forlan, 22 Diego Milito, 28 Mauro Zarate, 30 Luc Castaignos
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!