It's Napoli-Fiorentina so the battle of the tridents as Hamsik-Lavezzi-Cavani take on Cerci-Vargas-Jovetic.
The Partenopei need to get back on track following their surprise defeat to Chievo midweek and welcome the Viola to the Stadio San Paolo for a 19.45 UK time kick-off.
Walter Mazzarri was under fire for changing seven of his starting XI against Chievo, so brings back the ‘Three Tenors' Marek Hamsik, Ezequiel Lavezzi and Edinson Cavani.
Salvatore Aronica is rested in the three-man defence, giving Ignacio Fideleff another chance after his howler gave away the goal in Verona.
Fiorentina amassed all their points on home turf so far and aim to change that in Naples.
Alberto Gilardino and Per Kroldrup are out of action, while Andrea Lazzari is still recovering from a flu virus.
Coach Sinisa Mihajlovic has opted to use Stevan Jovetic as a centre-forward in his trident attack, flanked by Alessio Cerci and Juan Manuel Vargas.
Riccardo Montolivo is again started despite his notorious contract dispute with the club.
Napoli: De Sanctis; Campagnaro, Cannavaro, Fideleff; Zuniga, Inler, Gargano, Dossena; Hamsik, Lavezzi; Cavani
Fiorentina squad: Boruc; Cassani, Gamberini, Natali, Pasqual; Behrami, Montolivo, Munari; Cerci, Jovetic, Vargas
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more