Andrea Pirlo faces his ex-teammates as Juventus take on Milan with Zlatan Ibrahimovic, Kevin-Prince Boateng and Antonio Cassano.
The two title contenders go head-to-head in Turin, kick-off at 19.45 UK time.
Antonio Conte has to do without Vincenzo Iaquinta and Paolo De Ceglie, but Pirlo is able to face his former teammates after shaking off a knock to the knee.
Giorgio Chiellini changes position to left-back, bringing in Andrea Barzagli with Leonardo Bonucci in the middle. Mirko Vucinic is the lone centre-forward in a 4-2-3-1 system.
Milan had far more concerns, as the absentee list includes Robinho, Alexandre Pato, Gennaro Gattuso, Philippe Mexes and Mathieu Flamini.
Ibrahimovic returned midweek after a thigh strain to face Viktoria Plzen in the Champions League, while Boateng and Massimo Ambrosini are back in the squad after long-term injuries.
Juventus: Buffon; Lichtsteiner, Barzagli, Bonucci, Chiellini; Pirlo, Marchisio; Krasic, Vidal, Pepe; Vucinic
Juventus bench: Storari, Grosso, Giaccherini, Pazienza, Del Piero, Matri, Elia
Milan: Abbiati; Bonera, Nesta, Thiago Silva, Zambrotta; Nocerino, Van Bommel, Seedorf; Boateng; Ibrahimovic, Cassano
Milan bench: Amelia, Antonini, De Sciglio, Aquilani, Emanuelson, Inzaghi, Ambrosini