Both Jeremy Menez and Ronaldinho have recovered from knocks to start as Roma travel to Cluj and Milan welcome Ajax.
The Rossoneri's fate is already decided, as they will go through in second place behind Real Madrid whatever happens this evening, but for Claudio Ranieri it's still up in the air.
Roma will qualify with at least a point away to Cluj, but even defeat could be enough as long as Basel don't beat Bayern in Munich.
David Pizarro, Simone Perrotta and John Arne Riise are out of action, while Menez was in doubt after missing last night's training session with a back problem.
Ranieri confirmed he would continue to enact the squad rotation system, making changes from the 2-2 draw at Chievo on Saturday.
Francesco Totti starts with Marco Borriello and Fabio Simplicio in midfield.
Cluj are without Tomas Costa, Gabriel Muresan and the suspended Italian Felice Piccolo, but ex-Napoli midfielder Roberto De Zerbi is back from injury.
Milan have made radical changes to their side for this game against Ajax, as the result is irrelevant for qualification.
There's still a chance for the Dutch side to secure third place and a move to the Europa League, but tension is sky high after Coach Martin Jol walked out on Monday night.
Frank de Boer is the caretaker Coach for this game at San Siro and wants a morale-boosting performance.
Teemu Tainio, Thimothee Atouba and Oleguer missed Saturday's game, while Florian Jozefzoon, Nicolas Lodeiro, Evander Sno and Kenneth Vermeer are long-term absentees.
The Rossoneri are without Pippo Inzaghi, Alexandre Pato and Massimo Oddo, but finally give Ronaldinho his first start after seven consecutive games on the bench.
There were some doubts as to whether the Brazilian would play after missing training with an ankle problem on Monday, but he gives Zlatan Ibrahimovic the chance to rest for the first time this season.
He's not the only one, as Alessandro Nesta, Gennaro Gattuso, Christian Abbiati and Ignazio Abate are also rested.
Cluj: Stancioiu; Panin, Cadù, Rada, Edimar; Konè, Dica, Kivuvu, Culio; De Zerbi, Traorè
Cluj bench: Nuno Claro, Tony, Alcantara, Rafael Bastos, Hora, Bjelanovic, Leo Veloso
Roma: Julio Sergio; Cassetti, Mexes, N Burdisso, Castellini, Brighi, De Rossi, Simplicio; Menez; Totti, Borriello
Roma bench: Lobont, Adriano, Juan, Greco, Taddei, Vucinic, Cicinho
Milan: Amelia; Bonera, Thiago Silva, Yepes, Antonini; Flamini, Pirlo, Ambrosini; Robinho, Seedorf, Ronaldinho
Milan bench: Roma, Ibrahimovic, Strasser, Papastathopoulos, Abate, Boateng, Merkel
Ajax: Stekelenburg; Van der Wiel, Alderweireld, Vertonghen, Emanuelson; Enoh, Eriksen, De Zeuww; Suarez, S De Jong, Sulejmani
Ajax bench: Verhoeven, Anita, El Hamdaoui, Ooijer, Lindgren, Tainio, Oleguer