Napoli have a full-strength line-up for their showdown with Bayern Munich, while Wesley Sneijder returns for Lille-Inter.
The Champions League matches kick off at 19.45 UK time and there are two Italian sides in action.
The San Paolo is packed out for the visit of German giants Bayern Munich, who are dominating the Bundesliga and are unbeaten since August 7.
Arjen Robben is out of action following groin surgery, but Franck Ribery is in the starting XI after recovering from a calf problem.
Napoli are fresh from a shock home defeat to Parma on Saturday night, but in the Champions League have beaten Villarreal and held Manchester City to a draw.
Goran Pandev and Marco Donadel are sidelined with long-term thigh problems, but the trio of Edinson Cavani, Ezequiel Lavezzi and Marek Hamsik start in attack.
Juan Zuniga steps in for a more protective tactic in midfield, replacing Andrea Dossena.
Inter hope to make up for Saturday's Serie A defeat to Catania, their second on the trot, and have Sneijder back in the side after a three-week lay-off, acting as trequartista behind Giampaolo Pazzini and Mauro Zarate.
Walter Samuel and Philippe Coutinho are absent with Luc Castaignos and Diego Forlan cup-tied, but Julio Cesar and Cristian Chivu return from injury.
Lille have lost just one of their last 31 games and have a full squad to choose from, including star strikers Moussa Sow and Eden Hazard.
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Gargano, Inler, Zuniga; Hamsik, Lavezzi; Cavani
Napoli bench: Rosati, Fideleff, Dossena, Fernandez, Santana, Dzemaili, Mascara
Bayern Munich: Neuer; Boateng, Van Buyten, Badstuber, Lahm; Tymoshchuk, Schweinsteiger; T Muller, Kroos, Ribery; Gomez
Bayern bench: Butt, Rafinha, Contento, Pranjic, Alaba, Luiz Gustavo, Olic
Lille: Enyama; Debuchy, Basa, Chediou, Beria; Balmont, Mavuba, Pedretti; Cole, Sow, Hazard
Lille bench: Mouko, Gueye, Payet, Obrianiak, Rozehnal, Bonmart, Jelen
Inter: Julio Cesar; Maicon, Lucio, Chivu, Nagatomo; Zanetti, Thiago Motta, Cambiasso; Sneijder; Pazzini, Zarate
Inter bench: Castellazzi, Caldirola, Jonathan, Stankovic, Obi, Crisetig, Milito
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!