Zlatan Ibrahimovic, Antonio Cassano and Kevin-Prince Boateng lead out Milan against BATE Borisov, as Taye Taiwo starts in defence.
Massimiliano Allegri has injury problems ahead of tonight's Champions League tie at San Siro.
Boateng returns to the side after his one-match ban against Palermo, but Thiago Silva and Clarence Seedorf joined the list of absentees.
These include Alexandre Pato, Gennaro Gattuso, Massimo Ambrosini, Mathieu Flamini and the ineligible Pippo Inzaghi and Stephan El Shaarawy.
Robinho is left on the bench despite netting in Serie A on Saturday evening and Daniele Bonera fills in for the injured Thiago Silva at centre-back with Taiwo getting a rare start on the left.
BATE Borisov need a big boost in this group after their 5-1 demolition at the hands of Barcelona.
They also visited San Siro 10 years ago, but were beaten 4-0 in the UEFA Cup.
Milan: Abbiati; Abate, Nesta, Bonera, Taiwo; Van Bommel, Aquilani, Nocerino; Boateng; Ibrahimovic, Cassano
Milan bench: Amelia, Mexes, Zambrotta, Yepes, Antonini, Emanuelson, Robinho
BATE Borisov: Gutor; Yurevich, Simic, Radkov, Bordachev, Kontsevoi, A Volodko, Likhtarovich, Baga, Renan Bressan; Kezman
BATE bench: Chesnovski, Gordeychuk, Pavlov, Aleksiyan, Olekhnovich, Rudik, Skavysh