Lecce must do without David Di Michele and Julio Sergio when welcoming Milan in the Sunday lunch-time kick-off.
The Stadio Via del Mare hosts this Serie A match starting from 11.30am UK time.
Di Michele, Souleymane Diamoutene and goalkeeper Julio Sergio all missed last week's test and are still out of action.
Stefano Ferrario and third choice shot-stopper Davide Petrachi are also absent, so Francesco Benassi is again in goal.
Lecce have lost all their home games so far this season, but can count on the fact Milan haven't won here since January 2002.
Lecce squad: Gabrieli, Benassi; Brivio, Esposito, Tomovic, Carrozzieri, Oddo; Giacomazzi, Mesbah, Olivera, Grossmuller, Piatti, Obodo, Strasser, Bertolacci, Giandonato; Corvia, Ofere, Cuadrado, Pasquato, Muriel