Roma have thrown Erik Lamela into the starting XI against Palermo in what is his debut for the club.
Luis Enrique makes changes after the last-gasp derby defeat to Lazio, some forced by injuries to Francesco Totti and Aleandro Rosi, while Simon Kjaer is suspended.
Miralem Pjanic failed a fitness test, so Argentine Lamela has his first game since the Under-20 World Cup.
It's a big risk for the Giallorossi, as Lamela has never actually played an official game for the club.
He is joined in attack by Pablo Daniel Osvaldo and Marco Borriello.
Palermo's Fabrizio Miccoli failed a fitness test, so he is on the bench, leaving Mauricio Pinilla to partner Abel Hernandez with Eran Zahavi in the trequartista role.
This is a transformation for Coach Devis Mangia, who was urged to abandon the 4-4-2 system by President Maurizio Zamparini.
Federico Balzaretti returns from suspension to complete the back four.
Roma: 24 Stekelenburg; 77 Cassetti, 29 Burdisso, 4 Juan, 3 Jose Angel; 16 De Rossi, 7 Pizarro, 19 Gago; 8 Lamela, 9 Osvaldo, 22 Borriello
Palermo: 33 Tzorvas; 31 Pisano, 3 Silvestre, 8 Migliaccio, 42 Balzaretti; 20 Acquah, 5 Barreto, 7 Della Rocca; 16 Zahavi; 11 Hernandez, 51 Pinilla
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!