Lazio have a decimated squad to face Catania, as Hernanes, Stefano Mauri, Alejandro Gonzalez and Francelino Matuzalem are out.
The Biancocelesti are in second place and could go top of the table after Wednesday night's Serie A games.
However, Coach Edy Reja has to reinvent his midfield due to an injury crisis.
Hernanes is the latest addition to the list of absentees along with Mauri, Gonzalez and Matuzalem.
In defence, Andre Dias will not be taking part due to a one-match ban.
At least there is some good news with the return to fitness of Cristian Brocchi.
Lazio squad: Bizzarri, Carrizo, Marchetti; Biava, Diakitè, Konko, Lulic, Radu, Scaloni, Stankevicius, Zauri; Brocchi, Cana, Del Nero, Ledesma; Cissè, Kozak, Klose, Rocchi, Sculli