Leaders Udinese have native Neapolitan Antonio Floro Flores for their trip to the San Paolo against a full-strength Napoli.
This is to all intents and purposes a Scudetto showdown, as the Friulani are top of the table and Napoli one of the contenders for the title, albeit already five points off the pace.
The most eagerly-awaited player was set to be Antonio Di Natale, but the Ballon d'Or candidate hasn't made the trip due to injury.
Also missing out are Mauricio Isla, Paulo Vitor Barreto and last-minute addition Maurizio Domizzi, so Damiano Ferronetti starts in defence.
Gabriel ‘the Romanian Leo Messi' Torje is therefore partnered by ex-Napoli striker and local boy Floro Flores.
Napoli miss Walter Gargano, Goran Pandev, Marco Donadel and Miguel Angel Britos, but Walter Mazzarri has largely shelved plans for squad rotation in this midweek round.
This means Edinson Cavani completes the attack with Marek Hamsik and Ezequiel Lavezzi.
It's a special match for Gokhan Inler, who spent four years with Udinese before the summer transfer.
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Dzemaili, Inler, Dossena; Hamsik, Lavezzi; Cavani
Udinese: Handanovic; Benatia, Danilo, Ferronetti; Basta, Pinzi, Asamoah, Badu, Armero; Torje, Floro Flores