Napoli have the ‘Three Tenors' as they take on Bayern in Munich, while Inter rely on Wesley Sneijder, Diego Milito and Mauro Zarate against Lille.
The Champions League continues this evening with Matchday 4, kicking off at 19.45 UK time.
Napoli are at the Allianz Arena and with their 1-1 draw in Italy are the only team to have taken points off Bayern in Group A so far.
Paolo Cannavaro, Walter Gargano, Marco Donadel and Miguel Angel Britos are out with thigh problems, while Goran Pandev finds a space on the bench despite picking up a thigh strain on October 1.
This means Blerim Dzemaili and Federico Fernandez step in to the starting XI, which is naturally led by ‘Three Tenors' Marek Hamsik, Ezequiel Lavezzi and Edinson Cavani.
Bayern Munich are without long-term absentees Arjen Robben and Breno, but Bastian Schweinsteiger and Daniel Van Buyten are available despite picking up knocks.
Inter may be struggling in Serie A, but they are in good shape for the Champions League, sitting on top of Group B.
However, both of their European wins have been away from home at CSKA Moscow and Lille respectively, having lost at San Siro to Trabzonspor when under Gian Piero Gasperini.
Claudio Ranieri hopes to break that home taboo when French champions Lille visit this evening, although he has to do without Douglas Maicon, Julio Cesar, Coutinho and Yuto Nagatomo.
On top of that injury list, Luc Castaignos, Diego Forlan and Andrea Poli are ineligible for the competition.
Sneijder is also suffering from a thigh problem and passed a late fitness test, while Milito had a stomach bug overnight.
It is therefore surprising that Milito and Zarate are in the starting XI with Giampaolo Pazzini on the bench, while Walter Samuel and Thiago Silva are thrown into the line-up despite injuries.
Lille are unbeaten in their last 13 away games in all competition. Chedjou, Balmont and Basa are all on the treatment table.
Bayern Munich: Neuer; Boateng, Van Buyten, Badstuber, Lahm; Luiz Gustavo, Schweinsteiger; Muller, Kroos, Ribery; Gomez
Bayern bench: Butt, Rafinha, Pranjic, Alaba, Tymoshchuk, Petersen, Olic
Napoli: De Sanctis; Campagnaro, Fernandez, Aronica; Maggio, Dzemaili, Inler, Zuniga; Hamsik, Lavezzi; Cavani
Napoli bench: Rosati, Grava, Fideleff, Dossena, Santana, Mascara, Pandev
Inter: Castellazzi; Zanetti, Lucio, Samuel, Chivu; Stankovic, Thiago Motta, Cambiasso; Sneijder; Milito, Zarate
Inter bench: Orlandoni, Ranocchia, Jonathan, Alvarez, Obi, Crisetig, Pazzini
Lille: Landreau; Debuchy, Rozehnal, Chedjou, Beria; J Cole, Mavuba, Pedretti, Hazard; Jelen, Sow
Lille bench: Enyeama, Souare', Bonnart, Gueye, Obraniak, Payet, De Melo
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!