Inter lost Wesley Sneijder in the warm-up for today's game against Cagliari on Davide Ballardini’s debut.
The Nerazzurri aim to get back on track at San Siro in the 17.00 UK time kick-off.
Claudio Ranieri has to do without Diego Forlan, Lucio, Douglas Maicon, Yuto Nagatomo, Sulley Muntari, Emiliano Viviano and the suspended Cristian Chivu.
This means revamping the defence with the return of Jonathan, Andrea Ranocchia and Walter Samuel, plus Javier Zanetti at left-back.
Sneijder was in the starting XI, but pulled out during the warm-up with a muscular problem, so Philippe Coutinho stepped in.
Cagliari sensationally sacked Massimo Ficcadenti last week and have brought in Ballardini as their third Coach of the campaign.
He had to make his decisions for this trip without Andrea Cossu, El Kabir, Davide Astori and Sebastian Eriksson.
Ex-Juventus and Bologna Swede Albin Ekdal is given the nod to take over the trequartista role behind strikers Thiago Ribeiro and Nene.
Inter: 1 Julio Cesar; 42 Jonathan, 23 Ranocchia, 25 Samuel, 4 Zanetti; 5 Stankovic, 8 Thiago Motta, 19 Cambiasso; 29 Coutinho; 28 Zarate, 7 Pazzini
Inter bench: 12 Castellazzi, 2 Cordoba, 18 Poli, 20 Obi, 22 Milito, Alvarez, 37 Faraoni
Cagliari: 1 Agazzi; 14 Pisano, 21 Canini, 3 Ariaudo, 31 Agostini; 8 Biondini, 5 Conti, 4 Nainggolan; 20 Ekdal; 19 Thiago Ribeiro, 18 Nené
Cagliari bench: 25 Avramov, 2 Gozzi, 9 Larrivey, 23 Ibarbo, 24 Parico, 30 Rui Sampaio, 32 Ceppelini