Napoli are taking no chances against a revamped Lazio at the Stadio San Paolo, while Djibril Cisse takes the centre-forward role.
The current Serie A leaders travel to Naples in a 19.45 UK time kick-off this evening.
Lazio have to do without Miroslav Klose, Stefano Mauri, Andre Dias, Libor Kozak, Simone Del Nero and Albano Bizzarri.
Cisse is therefore moved into the centre-forward position to replace Klose with support from Hernanes and Giuseppe Sculli.
Napoli have a decisive Champions League clash with Manchester City coming up on Tuesday, but Coach Walter Mazzarri is taking no chances.
The only changes are Andrea Dossena in for the not 100 per cent fit Juan Zuniga and Blerim Dzemaili replacing Walter Gargano, as the ‘Three Tenors’ Marek Hamsik, Ezequiel Lavezzi and Edinson Cavani.
Napoli: 1 De Sanctis; 14 Campagnaro, 28 Cannavaro, 6 Aronica; 11 Maggio, 20 Dzemaili, 88 Inler, 8 Dossena; 17 Hamsik, 22 Lavezzi; 7 Cavani
Napoli bench: 83 Rosati, 21 Fernandez, 23 Gargano, 3 Fideleff, 9 Mascara, 29 Pandev, 99 Lucarelli
Lazio: 83 Marchetti; 29 Konko, 21 Diakitè, 33 Stankevicius, 26 Radu; 32 Brocchi, 24 Ledesma; 19 Lulic, 8 Hernanes, 7 Sculli; 99 Cisse
Lazio bench: 84 Carrizo, 5 Scaloni, 2 Stendardo, 27 Cana, 15 Gonzalez, 11 Matuzalem, 9 Rocchi