Look ahead to all this weekend’s games, including four on Super Saturday with Lazio-Juventus, Atalanta-Napoli, plus Sunday’s Palermo-Fiorentina.
It’s potentially a huge turning point in the campaign for many clubs and the fixture list is reshuffled to suit Coppa Italia and Europa League commitments.
Lazio and Juventus were joint leaders going into this weekend, so they go head-to-head in a Scudetto showdown at the Stadio Olimpico, where the Bianconeri have a remarkable record.
Napoli are capable of sinking Manchester City’s millionaires, but can they do the same against an Atalanta side unbeaten on home turf?
Lecce-Catania and Novara-Parma provide intriguing relegation tussles in the 17.00 UK time kick-offs.
On Sunday Inter face a tricky trip to Siena and Milan welcome giant-killers Chievo.
Above all, Delio Rossi visits his old club for the first time since walking away in the summer, as Fiorentina step into the passionate Stadio Barbera arena.
Click here  to read all the in-depth match previews with statistics, records and team news.