Napoli have the Three Tenors to take on a weakened Villarreal as they fight to reach the last 16 of the Champions League.
The Partenopei need to win in Spain to be sure of going through in second place behind Bayern Munich, sending Manchester City into the Europa League, regardless of the City-Bayern result.
Salvatore Aronica had some injury concerns ahead of this game, while he and Christian Maggio are also just one booking away from a ban.
Villarreal have so far lost all five of their Champions League Group A matches and already know this is their last European tie of the season.
Giuseppe Rossi is a long-term absentee, but last-minute additions to that list are Borja Valero due to a bout of gastroenteritis and Cani with a knock to the right leg.
However, Javier Manunas and ex-Udinese defender Cristian Zapata have recovered, while Nilmar returned from his 10-week lay-off at the weekend.
Villarreal’s poor form does not only extend to Europe, as they have won only four of their last 25 matches in all competition since May 8.
Villarreal: Diego Lopez; Angel Lopez, Zapata, Musacchio, Oriol, De Guzman, Bruno Soriano, Senna, Perez, Marco Ruben, Nilmar
Villarreal bench: Cesar Sanchez, Gonzalo Rodriguez, Marchena, Mario Gaspar, Camunas, Gullon, Joselu
Napoli: De Sanctis; Aronica, Cannavaro, Campagnaro; Maggio, Gargano, Inler, Zuniga; Hamsik, Lavezzi; Cavani
Napoli bench: Rosati, Grava, Dossena, Fernandez, Santana, Dzemaili, Pandev