Milan have Kevin-Prince Boateng, Alexandre Pato and Zlatan Ibrahimovic leading the way against Bologna’s Marco Di Vaio and Alessandro Diamanti.
The Rossoneri hope to continue their climb up the Serie A standings and have packed the midfield with quality.
Clarence Seedorf, Alberto Aquilani and Mark Van Bommel all start, as Antonio Nocerino and Mathieu Flamini are injured.
Also absent for Massimiliano Allegri are Alessandro Nesta, Christian Abbiati, Gianluca Zambrotta, Gennaro Gattuso and Antonio Cassano, while Robinho is rested.
Bologna have Nico Pulzetti suspended, but veteran Di Vaio partners Diamanti in attack with support from Gaston Ramirez.
Jorge Crespo is given a rare start in defence ahead of Gyorgy Garics.
Bologna: Gillet; Crespo, Raggi, Portanova, Morleo; Casarini, Mudingayi, Kone; Ramirez; Diamanti, Di Vaio
Milan: Amelia, Abate, Thiago Silva, Yepes, Antonini, Aquilani, Van Bommel, Seedorf, Boateng, Pato, Ibrahimovic