Luis Enrique reshuffles with Francesco Totti starting and Daniele De Rossi at centre-back against Juventus this evening.
Serie A Week 15 concludes with the 19.45 UK time kick-off at the Stadio Olimpico between the unbeaten Bianconeri and Giallorossi in crisis.
It has been a difficult few weeks for Roma, who have lost two on the bounce and saw fans protest at the train station on their return from the 3-0 defeat to Fiorentina.
Because of red cards in that game, Juan, Fernando Gago and Bojan Krkic are all suspended. They join the injured Marco Cassetti, David Pizarro, Simon Kjaer, Fabio Borini and Nicolas Burdisso.
Totti has now recovered from his injury and is thrown back into the starting XI with Erik Lamela and the returning Pablo Daniel Osvaldo.
De Rossi has to be used at centre-back to fill the gaps, while Rodrigo Taddei is again used as a full-back.
Youth team player Federico Viviani is thrown in for his full Serie A debut in midfield, aged just 19.
Juventus will be joint top of the table with a point, though a win would put them ahead of Udinese.
The only absentee is ex-Roma striker Mirko Vucinic, who is replaced by Marcelo Estigarribia in the trident with Simone Pepe and Alessandro Matri.
Roma: Stekelenburg; Taddei, De Rossi, Heinze, Josè Angel; Pjanic, Viviani, Greco; Lamela, Totti, Osvaldo
Roma bench: Lobont, Cicinho, Rosi, Simplicio, Perrotta, Caprari, Borriello
Juventus: Buffon; Lichtsteiner, Barzagli, Bonucci, Chiellini; Vidal, Pirlo, Marchisio; Estigarribia, Matri, Pepe
Juventus bench: Storari, Pazienza, De Ceglie, Elia, Giaccherini, Del Piero, Quagliarella
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!