Napoli use the Three Tenors, while Roma have their own trident of Francesco Totti, Erik Lamela and Pablo Daniel Osvaldo.
Both sides have had stuttering form in Serie A this season, as the Partenopei balance it with their Champions League commitments, while the Giallorossi struggled to learn new Coach Luis Enrique’s tactics.
Roma welcome back Bojan Krkic and Juan from suspension, though Miralem Pjanic is banned with Fabio Borini, Simon Kjaer, Marco Cassetti, Fernando Gago and Nicolas Burdisso all injured.
Enrique reshuffles again by bringing in Aleandro Rosi and Fabio Simplicio. Totti is the trequartista behind Lamela and Osvaldo.
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Inler, Gargano, Dossena; Hamsik, Lavezzi; Cavani
Napoli bench: Rosati, Fernandez, Zuniga, Dzemaili, Santana, Pandev, Mascara
Roma: Stekelenburg; Rosi, Juan, Heinze, Taddei; Simplicio, De Rossi, Greco; Totti; Osvaldo, Lamela
Roma bench: Curci, Jose Angel, Rosi, Cicinho, Perrotta, Viviani, Borriello, Bojan