Kevin-Prince Boateng, Robinho and Zlatan Ibrahimovic face Marco Borriello, Jeremy Menez and Adriano in tonight's Milan-Roma.
The Rossoneri will end 2010 on top of the table regardless of this result, but hope to maintain their six-point advantage as well as knocking Roma out of the race.
Both sides are struggling with injuries for this game. Alexandre Pato, Pippo Inzaghi, Mathieu Flamini and Gianluca Zambrotta are out for the home side.
They have chosen Boateng as support for Ibrahimovic and Robinho, leaving Clarence Seedorf and Ronaldinho on the bench.
Roma had to leave Mirko Vucinic, Marco Cassetti, Simone Perrotta and Bogdan Lobont behind, but welcome back Daniele De Rossi. Julio Sergio is only fit for the bench.
There were question marks over whether Francesco Totti would start, but he has been dropped along with David Pizarro.
Claudio Ranieri continues his squad rotation system by fielding ex-Milan striker Borriello and former Inter star Adriano up front.
Milan: Abbiati; Abate, Nesta, Bonera, Antonini; Gattuso, Ambrosini, Pirlo; Boateng; Ibrahimovic, Robinho
Roma: Doni; Burdisso, Mexes, Juan, Riise; Brighi, De Rossi, Simplicio; Menez; Borriello, Adriano