Francesco Totti, Erik Lamela and Bojan Krkic lead the way with a fit-again Daniele De Rossi against Catania tonight.
There were injury doubts over De Rossi, but he has recovered in time to start the match at the Stadio Massimino.
Another surprise is the return of Simon Kjaer in central defence with Juan, leaving Gabriel Heinze on the bench.
The trident of Lamela, Totti and Bojan continues in attack, while Aleandro Rosi and Rodrigo Taddei are the full-backs.
Catania: Campagnolo; Potenza, Legrottaglie, Spolli, Alvarez; Izco, Lodi, Almiron; Barrientos, Bergessio, Gomez
Catania bench: Kosicky, Bellusci, Ricchiuti, Delvecchio, Llama, Maxi Lopez, Catellani
Roma: Stekelenburg; Rosi, Kjaer, Juan, Taddei; Simplicio, De Rossi, Pjanic; Lamela, Totti, Bojan
Roma bench: Lobont, Heinze, José Ángel, Gago, Greco, Perrotta, Caprari, Borini
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!